Abstract
Objectives To explore the cardiovascular risk attributable to menopausal status in a 9-year follow-up, population-based study.
Method All middle-aged women who met our eligibility criteria were selected from the Tehran Lipid and Glucose Study cohort. Data were collected by face-to-face interviews, physical examination and biochemical assessments at 3-year intervals. The World Health Organization classification was used to define menopausal status. Cardiovascular events that occurred in the cohort were investigated by a panel of medical specialists.
Results Based on menopausal status, there were no significant differences in cardiovascular disease after adjustment for age, body mass index and other confounders; however, significant relationships between serum concentrations of low density cholesterol and total cholesterol and menopausal status were observed.
Conclusions Menopause, independent of other cardiovascular disease risk factors, incurred cardiometabolic risk.
ACKNOWLEDGEMENTS
We are indebted to each of the study participants for the substantial time and effort contributed to this study. Acknowledgements are also due to the research staff at the Tehran Lipid and Glucose Study Unit. Our special thanks to Mrs N. Shiva for critical editing of English grammar and syntax of the manuscript. The authors also thank the National Council of Scientific Research of I.R. Iran for approval of the TLGS project and its funding as a national research project.
Conflict of interest The authors report no conflict of interest. The authors alone are responsible for the content and writing of this paper.
Source of funding National Council of Scientific Research of Islamic Republic of Iran.