Relation of myeloperoxidase-463G/A polymorphism with metabolic syndrome and its component traits in Egyptian women

Abstract

Context: Myeloperoxidase is a heme protein secreted by activated macrophages and generates intermediates that oxidize lipoproteins. Myeloperoxidase-463G/A is a functional polymorphism involved in regulation of myeloperoxidase expression.

Objective: The aim of this study is to assess the relation of myeloperoxidase-463G/A polymorphism with metabolic syndrome and its component traits in Egyptian women from the Suez Canal area.

Methods: The study includes 100 healthy female subjects and 100 metabolic syndrome patients. The component traits of metabolic syndrome are determined and the genotypes of the polymorphisms assessed using the PCR-RFLP technique.

Results: There was no significant difference in the allele frequencies between the metabolic syndrome and control groups. However, the GA and AA genotypes were associated with lower total cholesterol, LDL-C, systolic and diastolic blood pressure in the patients.

Conclusion: Myeloperoxidase-463G/A polymorphism is not associated with the incidence of metabolic syndrome.

• HDL
• lipoproteins
• LDL
• Peroxidase

Declaration of interest

The authors report no declarations of interest.