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Modern Rheumatology Volume 26, 2016 - Issue 3
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Case Report

Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis

Hayakazu SumidaDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Yoshihide AsanoDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanCorrespondence[email protected]
,
Masaru HatanoDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
,
Naohiko AozasaDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Tetsuo ToyamaDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Kaname AkamataDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Miki MiyazakiDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Takashi TaniguchiDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Takehiro TakahashiDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Yohei IchimuraDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Shinji NodaDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Yoshihiro KuwanoDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
,
Koichi YanabaDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
&
Shinichi SatoDepartment of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
 show all
Pages 454-457 | Received 17 Dec 2013, Accepted 16 Jan 2014, Published online: 04 Mar 2014
 
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Abstract

Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.

Acknowledgments

None.

Conflicts of interest

None.

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