The insulin-like growth factor 2 receptor gene Gly1619Arg polymorphism and idiopathic recurrent spontaneous abortion

Abstract

Objective. The insulin-like growth factor 2 (IGF2) and its receptor (IGF2R) are important regulators of placental function and fetal growth. Our aim was to investigate the association between IGF2R gene Gly1619Arg G>A polymorphism and recurrent spontaneous abortion (RSA).

Methods. Polymerase chain reaction and restriction fragment length polymorphism methods were performed to identify the genotypes in 149 couples with a history of at least three consecutive spontaneous abortions and 149 age-matched, unrelated, and fertile couples.

Results. There were no statistically significant differences in genotype or allele frequency among the couples with RSA and healthy controls.

Conclusions. We found no evidence that the IGF2R Gly1619Arg variation is associated with RSA.

Keywords:

• Pregnancy
• gene polymorphisms
• placenta
• miscarriage

Acknowledgments

The results of this study are part of the HuMGeN (Human Miscarriage Genetic Network) international project started by research groups from Slovenia and Croatia and our aim is to collect clinically relevant material and test candidate genes through association and expression studies. This research was part of the project ‘Genetic factors in etiology of recurrent spontaneous abortion’ and was supported by Ministry of Science, Education and Sports, Zagreb, Croatia.

Declaration of interest: The authors report no declaration of interest. The authors alone are responsible for the content and writing of the paper.