Umbilical cord blood concentration of soluble scavenger receptor for hemoglobin, but not pentraxin 3, is of value for the early postpartum identification of the presence of histological chorioamnionitis

Abstract

Objective: To determine whether umbilical cord blood concentrations of soluble scavenger receptor for hemoglobin (sCD163) and pentraxin 3 (PTX3) are of value in the early postpartum diagnosis of histological chorioamnionitis in preterm prelabor rupture of membranes (PPROM). Methods: Eighty-three women with pregnancies complicated by PPROM between 24 and 36 weeks of gestation with (n = 38) and without (n = 45) the presence of histological chorioamnionitis were included in the study. We compared umbilical cord blood sCD163 and PTX3 levels in preterm neonates from PPROM pregnancies with versus without the presence of histological chorioamnionitis using nonparametric test (Mann–Whitney U test). Results: The presence of histological chorioamnionitis was associated with a higher median umbilical cord blood sCD163, but not PTX3 concentration, to compare with the absence of histological chorioamnionitis [sCD163: median 1466 ng/mL, interquartile range (IQR) 1187–1828 vs. 1168 ng/mL, IQR 887–1595; p = 0.01; PTX3: median 3.96 ng/mL, IQR 2.24–6.77 vs. 2.95 ng/mL, IQR 1.74–6.93; p = 0.49]. Conclusions: HCA is associated with an increase of umbilical cord blood sCD163, but not PTX3 concentration. Umbilical cord blood sCD163 seems to be a postpartum marker of the presence of histological chorioamnionitis.

Keywords::

• Umbilical cord blood
• sCD163
• PTX3
• histological chorioamnionitis
• PPROM

Acknowledgements

This work was supported by a grant from The Internal Grant Agency (NS 10382-3/2009) Ministry of Health of the Czech Republic and by Research project MZO 00179906.

Declaration of interest: There is no conflict of interest for any authors of this study.