Nasal intermittent mandatory ventilation versus nasal continuous positive airway pressure for transient tachypnea of newborn: a randomized, prospective study

Abstract

Objective: To evaluate the efficacy of nasal intermittent mandatory ventilation (NIMV) in reducing the duration of respiratory distress compared with nasal continuous positive airway pressure (NCPAP) in transient tachypnea of the newborn (TTN).

Patient and methods: İn this randomized-prospective study, 40 infants with a gestational age ≥37 weeks and birth weight ≥2000 g with TTN were randomized to either nonsynchronized NIMV (n = 20) or NCPAP (n = 20). The primary end point was the reduction of the duration of respiratory distress. Secondary end points were the duration and level of oxygen supplementation, the incidence of complications such as pneumothorax, pneumonia and respiratory failure requiring entubation.

Results: There were no significant difference in the duration of respiratory support (28.0 ± 19.2 h versus 32.2 ± 23.3 h, p = 0.231), O₂ therapy (31.2 ± 15.6 h versus 29.0 ± 19.3 h, p = 0.187), duration of TTN (67.6 ± 36.5 h versus 63.3 ± 39.1 h, p = 0.480) and hospitalization (6.2 ± 2.6 d versus 5.4 ± 2.0 d, p = 0.330) between the groups. The rate of complications were not significantly different between the groups.

Conclusion: Our study indicates that NIMV is well tolerated and as effective as NCPAP in the treatment of TTN.

• Nasal continuous positive airway pressure
• nasal intermittent mandatory ventilation
• transient tachypnea of newborn

Notes

*Clinical trial registration number: NCT01499238.