Abstract
Objective: In the present study, the effects of povidone iodine (PI) used during Caesarean operations on maternal thyroid hormones and urine iodine levels in the infant and the mother were investigated.
Design: Twenty-seven patients were allocated to the PI group I (Gr I), and 28 to the non-PI group (Group II). Maternal preoperative and 24th-h postoperative free T3 (fT3), freeT4 (fT4), TSH, and urine iodine levels were determined, as well as infant urine iodine values.
Results: In both groups, fT3 levels before and after the operation were found to be reduced (p < 0.01, p = 0.01, respectively). However, the decrease in fT3 was approximately 1.5-fold higher in Gr I than in Gr II. TSH levels increased significantly in Gr I (p = 0.005). The urine iodine levels of the mothers increased 25% in Gr I, but only 2% in Gr II.
Conclusions: The absorption of PI by the skin was found to lead to changes in fT3, TSH, and urine iodine excretion values in the mothers. The findings of this study of Caesarean operations, which have a short duration, might be a signal to be careful of thyroid hormone effects in operations lasting longer.
Acknowledgements
Rahime Bedir Findik worked on the collection and assembly of data, writing the article, critical revision of the article, research concept and design. Gulsen Yilmaz performed the data analysis and interpretation. Huseyin Tugrul Celik managed the final approval of the article. Fatma Meric Yilmaz performed the data analysis and interpretation. Ugur Hamurcu worked on the collection and assembly of data and Jale Karakaya for stastical analysis.