Protective effects of Danshensu on liver injury induced by omethoate in rats

Abstract

This study was to evaluate the protective effects of Danshensu on liver injury induced by omethoate in Sprague Dawley rats. The acute omethoate poisoning model was established by administrating subcutaneously with omethoate at a single dose of 60 mg/kg. Danshensu treatment markedly inhibited the increases of aspartate aminotransferase, alanine aminotransferase, cyclooxygenase-2, tumor necrosis factor-alpha, thromboxane B₂, and thromboxane B₂/6-keto-PGF1alpha ratio induced by omethoate. The histopathological examination further confirmed that administration with Denshensu ameliorated liver injury. The results demonstrated that Danshensu possesses protective action on hepatic injury induced by omethoate and the pharmacological mechanism was related to the anti-inflammatory effect and circulation improvement of Danshensu, at least in part.

Keywords::

• Danshensu
• omethoate
• acute poisoning
• liver injury

Acknowledgements

The authors would like to thank Dr Yongtang Xiao for technical assistance. The authors also thank Dr Liu Shutai for the English revision.

Declaration of interest

This study was supported by the Key Programs for Science and Technology Development of Shandong Province (No. 2007ZH10901), International S&T Cooperation Program of China (No. 2009DFA31100), and Shandong Provincial Natural Science Foundation, China (No. ZR2009CQ004). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.