Endocrine Regulation of Neonatal Hypoxia: Role of Glucose, Oxygen, and Epinephrine Supplementation

Abstract

Responses of the endocrine system are vital in revealing the mechanisms of respiratory activities. The present study focused on changes in insulin and triiodothyronine concentration in serum, its receptors in the hearts of hypoxic neonatal rats and glucose, oxygen, and epinephrine resuscitated groups. The insulin concentration was significantly increased with a significant upregulation of receptors in hypoxic neonates. Triiodothyronine content and its receptors were significantly decreased in serum and the hearts of hypoxic neonates. The change in hormonal levels is an adaptive modification of the endocrine system to encounter the stress. The effectiveness of glucose resuscitation to hypoxic neonates was also reported.

Keywords :

• insulin
• triiodothyronine
• neonatal hypoxia
• glucose
• oxygen
• epinephrine

ACKNOWLEDGMENTS

This work was supported by the research grants from DBT, DST, ICMR, the government of India and KSCSTE, the government of Kerala, and to Dr. C. S. Paulose. Anju T R thanks the Council of Scientific and Industrial Research for a senior research fellowship.