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Fetal and Pediatric Pathology Volume 32, 2013 - Issue 2
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Research Article

Usefulness of OCT4/3 Immunostain in Pediatric Malignant Germ Cell Tumors

Sarah TalebaghaChildren's Healthcare of Atlanta, Department of Pathology, Atlanta, Georgia, USA
,
Christine RizkChildren's Healthcare of Atlanta, Department of Pathology, Atlanta, Georgia, USA
,
Nancy ElawabdehChildren's Healthcare of Atlanta, Department of Pathology, Atlanta, Georgia, USA
,
Carlos R. AbramowskyChildren's Healthcare of Atlanta, Department of Pathology, Atlanta, Georgia, USA
&
Bahig M. ShehataChildren's Healthcare of Atlanta, Department of Pathology, Atlanta, Georgia, USACorrespondence[email protected]
Pages 82-87 | Published online: 16 Apr 2012
 
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Abstract

Octamer4/3 is a POU transcription factor that regulates pluripotentiality in embryonic stem and germ cells and primordial germ cells. When expressed in post-embryonic life, Octamer4/3 may lead to malignant germ cell tumors (GCT). Thirty samples were selected for this study (26 GCT samples and 4 cryptorchid testes samples) and 16 non-GCT were used as controls. Samples were stained with an anti-Octamer4/3 antibody. All cases of GCT were positive for Octamer4/3, and the non-GCT were negative. This article focuses on pediatric populations where we found that Octamer4/3 immunostaining is a useful diagnostic tool in undifferentiated pediatric tumors.

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