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Toxin Reviews Volume 32, 2013 - Issue 3
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Review Article

Is N-acetyl cysteine protective against monocrotaline-induced toxicity?

Serife KaragozDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University EskisehirTurkey
,
Sinem IlginDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University EskisehirTurkeyCorrespondence[email protected]
,
Ozlem AtliDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University EskisehirTurkey
,
Basak Ozlem PerkDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University EskisehirTurkey
,
Dilek BurukogluDepartment of Histology
,
Bulent ErgunDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University EskisehirTurkey
&
Basar SirmagulDepartment of Pharmacology, Faculty of Medicine, Osmangazi University EskisehirTurkey
 show all
Pages 47-54 | Received 16 Apr 2013, Accepted 25 May 2013, Published online: 19 Jul 2013
 
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Abstract

Monocrotaline (MCT) is a pyrrolizidine alkaloid which induces cardio-pulmonary toxicity and hepatotoxicity in animals and humans. MCT is frequently ingested because of food grain contamination accidentally or in the form of herbal medicine preparations. The aim of this study was to observe the protective effect of N-acetyl cysteine (NAC) on MCT-induced pulmonary toxicity and hepatotoxicity. According to our results (right ventricular pressures [RVPs], ratios of right ventricle (RV)/heart weight (HW), plasma AST levels, liver glutathione levels, liver MDA levels and liver histopathological examinations of groups), protective effects were observed with NAC treatment in both MCT-induced pulmonary toxicity and hepatotoxicity.

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