Translational research approach to biological and modifiable risk factors of psychosis and affective disorders

Abstract

Objectives. This review summarizes the literature on (molecular-) biological, medical, environmental and modifiable risk factors for psychosis and mood disorders with the view of their suitability for translational research and mental health practice from preventative and clinical treatment perspectives. Methods. This review summarized literature on biological, medical, environmental and modifiable risk factors for psychosis and mood disorders evaluating their potential for translational research and clinical practice. Results. Based on the concept of the gene – environment interaction in the development of mental disorders, we highlight the numerous risk factors reported to contribute to an increased susceptibility to schizophrenia and mood disorders of young adults to late-life. Special emphasis is placed onto the discussion on the requirement of translational and interdisciplinary research approaches integrating basic and clinical neuroscience approaches that may have important implications for future studies and clinical practice. Conclusions. Interdisciplinary research approaches integrating developmental neuroscience and policy makers are encouraged in order to achieve effective prevention and intervention programs addressing environmental, behavioural, biological factors relevant to psychiatric disorders during young ages, adulthood and aging.

Key words::

• Schizophrenia
• depression
• comorbidity
• genes
• environment
• translational psychiatry
• neuroscience
• epidemiology

Acknowledgements

None

Statement of interest

The authors have no conflicts of interest, and are solely responsible for the content and writing of the paper.