Analysis of association between common variants in the SLCO6A1 gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population

Abstract

Objectives The SLCO6A1 gene belongs to a superfamily of genes which is known to be a solute carrier family of OATPs (SLCO). The SLCO6A1 gene encodes OATP6A1 protein in humans. A previous genome-wide association study (GWAS) of schizophrenia conducted in the Swedish population demonstrated a significant association of rs6878284, which is located in the SLCO6A1 gene, with schizophrenia. To further investigate whether this gene is also a risk locus for schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD) in the Han Chinese population, a case–control study was designed. Methods In total 1,248 unrelated SCZ cases, 1,344 BPD cases, 1,056 unrelated MDD cases and 1,248 normal controls were analysed in this study. We genotyped five SNPs using the Sequenom MassARRAY platform. Results We found no association of rs6878284 with SCZ [Corrected P_allele= 0.969, Corrected P_genotype= 0.997]. Furthermore, we found a statistically significant association of the rs7734060 genotype with MDD after correction [rs7734060: Corrected P_allele = 0.114, Corrected P_genotype = 0.036] in the Han Chinese population. Conclusions This is the first study which reveals no association of rs6878284 with SCZ and also predicts that rs7734060 could be a risk locus for MDD in the Han Chinese population.

Keywords:

• Major depressive disorder
• case–control study
• SLCO6A1
• genetic association
• Han Chinese

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Corrigendum

Acknowledgements

We thank and acknowledge all the participants of this study. This work was supported by the 973 Program (2015CB559100), the National 863 project (2012AA02A515, 2012AA021802), the Natural Science Foundation of China (31325014, 81130022, 81272302, 81121001, 81171271), Shanghai Key Laboratory of Psychotic Disorders (13dz2260500), the Research Project of Shanghai Health and Family Planning Commission (20134315), “Shu Guang” project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation (12SG17), the Shanghai Jiao Tong University Liberal Arts and Sciences Cross-Disciplinary Project (13JCRZ02) and “the Program of Shanghai Academic Research Leader (15XD1502200)”.

Statement of interest

None to declare.