Indomethacin for prevention of heterotopic ossification after hip arthroplasty: A randomized comparison between 4 and 8 days of treatment

Ulrich Dorn Orthopedic Department, Salzburg General Hospital, Mullner Hauptstrasse 48, A-5020, Salzburg, Austria, Tel +43 662-4482/2900, Fax -4482/2903

Claude Grethen Orthopedic Department, Salzburg General Hospital, Mullner Hauptstrasse 48, A-5020, Salzburg, Austria, Tel +43 662-4482/2900, Fax -4482/2903

Harald Effenberger Orthopedic Department, Salzburg General Hospital, Mullner Hauptstrasse 48, A-5020, Salzburg, Austria, Tel +43 662-4482/2900, Fax -4482/2903

Hans Berka Orthopedic Department, Salzburg General Hospital, Mullner Hauptstrasse 48, A-5020, Salzburg, Austria, Tel +43 662-4482/2900, Fax -4482/2903

Thomas Ramsauer Orthopedic Department, Salzburg General Hospital, Mullner Hauptstrasse 48, A-5020, Salzburg, Austria, Tel +43 662-4482/2900, Fax -4482/2903

Thomas Drekonja Orthopedic Department, Salzburg General Hospital, Mullner Hauptstrasse 48, A-5020, Salzburg, Austria, Tel +43 662-4482/2900, Fax -4482/2903

Abstract

In a randomized, parallel group study, we evaluated the efficacy of a 4-day versus an 8-day course of indomethacin (50 mg, 3 times per day), given as prophylaxis against heterotopic ossification after formation. cementless total hip arthroplasty in 209 patients with arthrosis. Patients receiving the prophylaxis for 8 days had less (p = 0.03) severe heterotopic bone

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Indomethacin for prevention of heterotopic ossification after hip arthroplasty: A randomized comparison between 4 and 8 days of treatment

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Indomethacin for prevention of heterotopic ossification after hip arthroplasty: A randomized comparison between 4 and 8 days of treatment

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