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Amyotrophic Lateral Sclerosis Volume 10, 2009 - Issue 5-6
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Original Article

Interactions with GluR1 AMPA receptors could influence the therapeutic usefulness of minocycline in ALS

Hari Manev The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USACorrespondence[email protected]
&
Radmila Manev The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Pages 416-417 | Received 30 Oct 2008, Published online: 18 Nov 2009
 
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Abstract

Despite the beneficial effects of minocycline seen in animal models of ALS, initial clinical trials of minocycline in ALS patients failed to support its expected therapeutic usefulness. Here we discuss new results from recent preclinical studies of the molecular neuronal effects of minocycline pertinent for better understanding of the therapeutic potential of this antibiotic.

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