Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease in adults of unknown origin in most cases. Here we report a novel P66S mutation in exon 3 of the SOD1 gene in an apparently sporadic ALS patient with unusual early onset and rapid disease progression. Our data widen the spectrum of SOD1 mutations and clinical presentations of ALS.
Declaration of interest: Zorica Stević is an appointed member of Editorial Advisory Board of Amyotrophic Lateral Sclerosis; the other authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.