Whole mitochondrial genome sequencing and analysis for rat squamous cell carcinoma tissue cell

Abstract

Mitochondrial genome plays a central role in aging, cancer, apoptosis and metabolism. Squamous cell carcinoma is one of the major types of non–small cell lung cancer. We sequenced a complete mitochondrial genome sequence of a rat squamous cell carcinomas cell tissue for the first time. The total length of the mitochondrial genome was 16,319 bp, with 13 protein-coding genes, two ribosomal RNA genes and 22 transfer RNA genes. This genome describing information will supply the potential use of mtDNA mutations as markers in cancer.

• Cancer
• mitochondrial genome
• squamous cell carcinoma

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.