Abstract
The acquired immunodeficiency syndrome (AIDS) in humans was one of the chronic infections caused by human immunodeficiency virus (HIV), and the interactions between viral infection and mitochondrial energetic implicated that mitochondrial DNA (mtDNA) variation(s) may effect genetic susceptibility to AIDS. Thus, to illustrate the maternal genetic structure and further identify whether mtDNA variation(s) can effect HIV infection among southwest Chinese AIDS group, the whole mtDNA control region sequences of 70 AIDS patients and 480 health individuals from southwest China were analyzed here. Our results indicated the plausible recent genetic admixture results of AIDS group; comparison of matrilineal components between AIDS and matched Han groups showed that mtDNA haplogroup A (p = 0.048, OR = 3.006, 95% CI = 1.109–8.145) has a significant higher difference between the two groups; further comparison illustrated that mtDNA mutations 16,209 (p = 0.046, OR = 2.607, 95% CI = 0.988–6.876) and 16,319 (p = 0.009, OR = 2.965, 95% CI = 1.278–6.876) have significant differences between AIDS and matched control groups, and both of which were the defining variations of mtDNA haplogroup A, they further confirmed that mtDNA haplogroup A may confer genetic susceptibility to AIDS. Our results suggested that haplogroup A may confer a genetic susceptibility to AIDS group from Southwest China.
Declaration of interest
Project funded by China Postdoctoral Science Foundation (No. 2014M562513XB), the key Joint Funds of the Natural Science Foundation of Yunnan Province and Kunming Medical University (No. 2011FB165), the Foundation of Yunnan Provincial Bureau of Health (No. 2011WS0008) and the Major project of Yunnan Provincial Bureau of Education (No. ZD2011007), the National Science Foundation of China (No. 81360069), Academician workstation of Yunnan Province, the Foundation for Innovative Group of the gastrointestinal surgery of Yunnan Province (No. 2012HC013), the Foundation of Medical Leading Talent of Yunnan Province (No. L-201205) and the Special Research Foundation of Intestinal Barrier of Academician Jie-Shou Li (No: LJS-201302). Authors declare that they do not have any financial, consulting, and personal relationships with other people or organizations that could influence the author’s work.
Supplementary material available online