Mitochondrial tRNA mutations in patients with myelodysplastic syndromes

Abstract

Increasing evidence showed that mitochondria play an important role in the development of myelodysplastic syndromes (MDS). Mitochondrial dysfunctions caused by mitochondrial DNA mutations, especially mitochondrial tRNA mutations, were found to be associated with MDS in many studies. However, the link between a candidate mitochondrial tRNA mutation and MDS was not clear. In this study, we investigated the role of some mitochondrial tRNA mutations, and their deleterious roles were further discussed.

• Association
• MDS
• mitochondrial tRNA mutations

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.