Health-related quality of life, personality and choice of coping are related in renal cell carcinoma patients

Abstract

Objective. To investigate whether health-related quality of life (HRQoL) depends on psychosocial factors, rather than on factors related to the cancer treatment, this study explored the associations between HRQoL, personality, choice of coping and clinical parameters in surgically treated renal cell carcinoma (RCC) patients. Materials and methods. After exclusions (e.g. death, dementia), 260 patients were found to be eligible and invited to participate. The response rate was 71%. HRQoL was determined by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30), personality by the Eysenck Personality Inventory and coping by the COPE Questionnaire. Given tumour treatment, TNM stage and patient-reported comorbidity were also determined. The HRQoL indices were also summarized in general quality of life/health, functional sum and symptom sum scores. Results. EORTC C30 sum scores were negatively associated with the personality trait of neuroticism [common variance (CV) 19–36%]. Avoidant choice of coping inversely accounted for 9–18% of the total HRQoL variance, while reported coping by humour was to some extent negatively associated with HRQoL score (CV_max 4%). Indeed, all of the quality of life indices except for one were significantly negatively correlated with neuroticism and avoidance coping. Patients with low HRQoL due to treatment, secondary to flank or open surgery, reported a closer association between problem-focused choice of coping and HRQoL than the other patients. Moreover, present comorbidities were uniquely associated with a lowered HRQoL. Conclusions. HRQoL is related to treatment-related factors in RCC patients, but shown here to be more strongly associated with psychological factors and present comorbidity. These findings suggest that attention should be paid to supportive treatment of RCC patients.

Keywords:

• Health-related quality of life
• psychological factors
• renal cell carcinoma patients

Declaration of interest: The authors have nothing to disclose, and the study has been carried out with no funding from sources other than the institutions mentioned on the title page. The authors alone are responsible for the content and writing of the paper.