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British Journal of Neurosurgery Volume 20, 2006 - Issue 4
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CaseReport

Disseminated intravascular coagulation complicating resection of a malignant meningioma

J. E. Brecknell Departments of NeurosurgeryCorrespondence[email protected]
,
C. A. Mclean Anatomical Pathology, Alfred Hospital, Prahran, Australia
,
H. Hirano Department of Neurosurgery, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
&
G. M. Malham Departments of Neurosurgery
Pages 239-241 | Received 01 Nov 2005, Accepted 19 Apr 2006, Published online: 06 Jul 2009
 
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Abstract

A 70-year-old woman developed disseminated intravascular coagulation (DIC) during a craniotomy for a parasagittal anaplastic/malignant meningioma. This was successfully treated with rapid resection of the tumour and haematological replacement, but a poor neurological outcome resulted. The tumour was demonstrated to express tissue factor, an important causative factor in other tumour associated DIC and previously shown to be expressed by malignant meningiomas. A link between the two is suggested.

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