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Leukemia & Lymphoma Volume 44, 2003 - Issue 7
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Research Article

Molecular Cytogenetic Approach to the Diagnosis of Splenic Lymphoma: A Case Report of Blastoid Mantle Cell Lymphoma

Erik Björck Department of Molecular Medicine, CMM L8:02 Karolinska Hospital and Institutet, 76, SE-171, Stockholm, Sweden
,
Ola Landgren Department of Hematology, Karolinska Hospital and Institutet, Stockholm, Sweden
,
Jacqueline Schoumans Department of Molecular Medicine, CMM L8:02 Karolinska Hospital and Institutet, 76, SE-171, Stockholm, Sweden
,
Birger Christensson Department of Pathology, Huddinge University Hospital, Karolinska Institutet, Stockholm, Sweden
,
Magnus Björkholm Department of Hematology, Karolinska Hospital and Institutet, Stockholm, Sweden
,
Anna Porwit MacDonald Department of Pathology and Cytology, Karolinska Hospital and Institutet, Stockholm, Sweden
&
Magnus Nordenskjöld Department of Molecular Medicine, CMM L8:02 Karolinska Hospital and Institutet, 76, SE-171, Stockholm, SwedenCorrespondence[email protected]
 show all
Pages 1229-1234 | Accepted 26 Nov 2002, Published online: 03 Aug 2009
 
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Abstract

A 69-year-old woman was admitted to hospital due to abdominal pain. An enlarged spleen was detected and extirpated. Histological examination and FACS analysis could not clearly differentiate between a splenic marginal zone lymphoma and a mantle cell lymphoma. Using molecular cytogenetic techniques, a complex karyotype including a translocation between chromosome 11 and 14 consistent with a triple fusion between heavy chain immunoglobulin locus (IgH) and cyclin D1 (CCND1) was demonstrated. Overexpression of cyclin D1 was detected by immunostaining. Thus the diagnosis of a splenic blastoid mantle cell lymphoma could be established. In this report, various aspects of differential diagnosis of splenic lymphomas are discussed.

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