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Leukemia & Lymphoma Volume 46, 2005 - Issue 11
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Follicular lymphoma with bilateral testicular and epididymal involvement: Case report and review of the literature

Eric Jacobsen Department of Medical Oncology, Dana-Farber Cancer Institute
,
Lesley Lomo Departments of Medicine and Pathology, Brigham and Women's Hospital, Departments of Medicine and Pathology, Harvard Medical School, Boston, MA
,
Frederick Briccetti Partner, New Hampshire Oncology-Hematology, Concord, NH, USA
,
Janina Longtine Departments of Medicine and Pathology, Brigham and Women's Hospital, Departments of Medicine and Pathology, Harvard Medical School, Boston, MA
&
Arnold Freedman Department of Medical Oncology, Dana-Farber Cancer InstituteCorrespondence[email protected]
, MD
Pages 1663-1666 | Received 04 May 2005, Published online: 01 Jul 2009
 
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Abstract

Testicular involvement with indolent lymphoma is extremely rare, particularly in the absence of transformation to an aggressive histology. We report a case of a 64-year-old man who presented with cervical lymphadenopathy. Staging CT scans revealed extensive lymphadenopathy as well as bilateral testicular and epididymal masses. Histologic examination of lymph node, bone marrow, and testicular/epididymal biopsies revealed involvement with grade I follicular lymphoma. The patient was started on chemotherapy with cyclophosphamide, vincristine, prednisone, and rituximab in addition to intrathecal methotrexate and testicular radiation. He is now 6 months into therapy and responding well. A review of the literature demonstrated this to be the first confirmed case of testicular and epididymal involvement with grade I follicular lymphoma.

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