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Drug Metabolism Reviews Volume 31, 1999 - Issue 1
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Research Article

P450 SUBFAMILY CYP2J AND THEIR ROLE IN THE BIOACTIVATION OF ARACHIDONIC ACID IN EXTRAHEPATIC TISSUES*

PAULA E. SCARBOROUGH Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, U.S.A.
,
JIXIANG MA Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, U.S.A.
,
WEI QU Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, U.S.A.
&
DARRYL C. ZELDIN Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709, U.S.A.
Pages 205-234 | Published online: 02 Aug 1999
 
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Abstract

Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.

Notes

* This paper was refereed by F. Peter Guengerich, Ph.D., Center in Molecular Toxicology, Department of Biochemistry, Vanderbilt University, Nashville, TN 37232.

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