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Scandinavian Journal of Infectious Diseases Volume 29, 1997 - Issue 5
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Original Article

Susceptibility of Chlamydia pneumoniae to Azithromycin and Doxycycline: Methodological Aspects on the Determination of Minimal Inhibitory and Minimal Bactericidal Concentrations

Christina Nyström-Rosander Departments of Infectious Diseases, University Hospital, Uppsala, Sweden
,
Kristina Hultén Departments of Clinical Microbiology, University Hospital, Uppsala, Sweden
,
Ingegerd Gustavsson Departments of Clinical Microbiology, University Hospital, Uppsala, Sweden
,
Otto Cars Departments of Infectious Diseases, University Hospital, Uppsala, Sweden
,
Lars Engstrand Departments of Clinical Microbiology, University Hospital, Uppsala, Sweden
&
Eva Hjelm Departments of Clinical Microbiology, University Hospital, Uppsala, Sweden
Pages 513-516 | Received 01 Apr 1997, Accepted 25 Jun 1997, Published online: 08 Jul 2009
 
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Abstract

An in vitro assay for measuring and comparing the efficacy of different antimicrobial agents against Chlamydia pneumoniae was developed. Azithromycin, a representative of the new azalide group of antibiotics, and doxycycline were evaluated with respect to their antibacterial effect and capacity for intracellular killing under different experimental conditions. For both study drugs, the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values increased significantly with longer bacterial preincubation time. The effect of different exposure times of antibiotics on the bacteria was also studied.

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