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Journal of Microencapsulation
Micro and Nano Carriers
Volume 31, 2014 - Issue 2
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Research Article

Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part II. Effect of process variables on protein model drug encapsulation efficiency

Quazi T. H. ShubhraDoctoral School of Molecular and Nanotechnologies, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungaryCorrespondence[email protected]
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Tivadar FeczkóResearch Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungary;Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Pusztaszeri u. 59-67, H-1025 BudapestHungary
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Andrea F. KardosResearch Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungary;Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Pusztaszeri u. 59-67, H-1025 BudapestHungary
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Judit TóthResearch Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungary;Institute of Materials and Environmental Chemistry, Research Center for Natural Sciences, Hungarian Academy of Sciences Pusztaszeri u. 59-67, H-1025 BudapestHungary
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Hana MackovaInstitute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic Heyrovsky Sq. 2, 16206 Prague 6Czech Republic
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Daniel HorakInstitute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic Heyrovsky Sq. 2, 16206 Prague 6Czech Republic
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György DósaDepartment of Mathematics, Faculty of Information Technology, University of Pannonia Veszprém, Egyetem u. 10Hungary
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János GyenisResearch Institute of Chemical and Process Engineering, Faculty of Information Technology, University of Pannonia Egyetem u.10, H-8200 VeszprémHungary
 show all
Pages 156-165 | Received 22 Jan 2013, Accepted 10 Jun 2013, Published online: 22 Jul 2013
 
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Abstract

This study investigates encapsulation efficiency of model drug, encapsulated by magnetic poly d,l-lactic-co-glycolic acid (PLGA) nanoparticles (NPs). This is the following part of our preceding paper, which is referred in this paper as Part I. Magnetic nanoparticles and model drug human serum albumin (HSA)-loaded PLGA NPs were prepared by the double emulsion solvent evaporation method. Among five important process variables, concentration of PLGA and concentration of HSA in the inner aqueous phase along with their cross-effect had the strongest influence on the encapsulation efficiency. Encapsulation efficiency of nanoparticles ranged from 18% to 97% depending on the process conditions. Higher encapsulation efficiencies can be achieved by using low HSA and high PLGA concentrations. The optimization process, carried out by exact mathematical tools using GAMSTM/MINOS software makes it easier to find out optimum process conditions to achieve comparatively high encapsulation efficiency (e.g. 92.3%) for relatively small-sized PLGA NPs (e.g. 155 nm).

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