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Current Eye Research Volume 7, 1988 - Issue 5
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Original Article

Comparison of conjunctival and corneal surface areas in rabbit and human

Mitchell A. Watsky Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 53226, USA
,
Monica M. Jablonski Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 53226, USA
&
Henry F. Edelhauser Medical College of Wisconsin, Department of Physiology, Milwaukee, WI, 53226, USA; Medical College of Wisconsin, Department of Ophthalmology, Milwaukee, WI, 53226, USA
Pages 483-486 | Received 11 Jan 1988, Accepted 18 Mar 1988, Published online: 02 Jul 2009
 
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Abstract

This comparative study shows the surface area ratio of conjunctiva to cornea to be two times larger in humans than in rabbits. This large heretofore unrecognized interspecies difference may affect the applicability of drug pharmacokinetic data obtained using rabbit models and should be taken into consideration in topical drug development and future comparative drug penetration studies between rabbit and man.

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