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Cancer Investigation Volume 1, 1983 - Issue 1
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Original Article

Survival in Childhood Acute Lymphocytic Leukemia: Effect of Protocol and Place of Treatment

Anna T. Meadows Children's Cancer Research Center, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Children's Hospital of Philadelphia, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Department of Pediatrics and Research Medicine University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
,
Shira Kramer Children's Cancer Research Center, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Children's Hospital of Philadelphia, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Department of Pediatrics and Research Medicine University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
,
Ron Hopson Children's Cancer Research Center, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Children's Hospital of Philadelphia, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Department of Pediatrics and Research Medicine University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
,
Edward Lustbader Children's Cancer Research Center, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Children's Hospital of Philadelphia, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Department of Pediatrics and Research Medicine University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
,
Patricia Jarrett Children's Cancer Research Center, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Children's Hospital of Philadelphia, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Department of Pediatrics and Research Medicine University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
&
Audrey E. Evans Children's Cancer Research Center, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Children's Hospital of Philadelphia, The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania; Department of Pediatrics and Research Medicine University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
Pages 49-55 | Published online: 11 Jun 2009
 
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Abstract

The objective of this study was to determine the effect of place and type of initial treatment on survival from acute lymphocytic leukemia (ALL). Every one of the 327 children under 15 years of age diagnosed with ALL from 1970 to 1975 in a 31-county area designated the Greater Delaware Valley, were studied. Treatment according to protocol was associated with improved survival, yielding a 4 year survival of 60% vs 19% for nonprotocol treated patients (p < 0.001). There was also a significantly improved survival rate among patients treated in a cancer center, especially for those with a low white blood count (WBC) at diagnosis. The prognostic importance of WBC, age, and sex was confirmed.

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