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Abstract
We evaluated multiple patient characteristics for their prognostic significance in patients with peripheral T-cell lymphoma (angioimmunoblastic T-cell lymphoma [AITL; n = 31] and peripheral T-cell lymphoma, not otherwise unspecified [PTCL-NOS; n = 37]). Five-year overall survival (OS) rates in AITL and PTCL-NOS were 49% and 45%, respectively (p = 0.89). Cox proportional hazard model revealed that male sex, hemoglobin <10.0 g/dL and performance status (PS) ≥2 were independently associated with shorter OS in AITL. In patients with PTCL-NOS, low albumin, PS ≥ 2, and mediastinal lymphadenopathy were independently associated with worse OS. When analysis in PTCL-NOS was performed incorporating Prognostic Index for PTCLu (PIT), low albumin and mediastinal lymphadenopathy were still both prognostic for OS. Three-year progression free survival (PFS) rates in AITL and PTCL-NOS were 49% and 47%, respectively (p = 0.578). None of the parameters was significantly associated with shorter PFS in AITL. In patients with PTCL-NOS, PS ≥ 2 and mediastinal lymphadenopathy were independently associated with shorter PFS. The result is in keeping with previous large scale studies. Besides, we showed the potential prognostic importance of albumin and mediastinal lymphadenopathy in patients with PTCL-NOS.
Acknowledgments
The authors would like to thank Dr. Keitaro Matsuo for his excellent support on statistical analysis, and also Ryoko Yamauchi, Aki Kobayashi, Yuka Owaki for their excellent secretarial support. D.C. contributed to the patient care, collected data, analyzed data and wrote the paper. Y. O. designed the study, contributed to the patient care, analyzed data and wrote the paper. S.I., K.Y., H.K., H.T., Y.K., and Y.M. contributed to the patient care and reviewed the paper. Y.Y. and S.N. provided pathological diagnosis and critically reviewed the paper. The authors reported no potential conflict of interest.