![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
The Philadelphia (Ph1) chromosome was the first specific chromosomal abnormality to be consistently associated with a particular neoplasm, in this case chronic myelogenous leukemia (CML,)1. Formed by a reciprocal translocation between chromosomes 9 and 222, the 22q-, or Ph1 chromosome is found in the malignant cells of more than 90% of patients with CML3. The presence of the molecular equivalent of a Ph1 chromosome is such a consistent finding in CML that it IS now the basis of a diagnostic test in routine clinical use.