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Leukemia & Lymphoma Volume 21, 1996 - Issue 1-2
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Original Article

Translocation t(8;16)(p11;p13) in Acute Non-Lymphocytic Leukemia: Report on Two New Cases and Review of the Literature

Elvira Rodrigues Pereira Velloso Center for Human Genetics, University of Perugia, Italy
,
Cristina Mecucci Hematology and Bone Marrow Transplantation Unit, University of Perugia, Italy
,
Lucienne Michaux Center for Human Genetics, University of Perugia, Italy
,
Angeline Van Orshoven Department of Clinical Biology, University of Perugia, Italy
,
Michel Stul Center for Human Genetics, University of Perugia, Italy
,
Marc Boogaerts Department of Hematology, University of Leuven, Italy
,
AndrÉ Bosly Department of Hematology, University of Louvain, Yvoir, Belgium
,
Jean-Jacques Cassiman Center for Human Genetics, University of Perugia, Italy
&
Herman Van Den Berghe Center for Human Genetics, University of Perugia, Italy
 show all
Pages 137-142 | Received 22 May 1995, Published online: 01 Jul 2009
 
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Abstract

Two new cases of t(8;16)(p11;p13) in acute nonlymphocytic leukemia (ANLL) are described. These two patients in addition to the 34 previously described, showed a striking association with myelomonocytic (M4) or monocytic (M5) leukemia, extramedullary infiltration, erythrophagocytosis and disseminated intravascular coagulation. One of our patients showed a TCRβ gene rearrangement. Alltogether 36 cases of t(8;16) ANLL have been documented until today. We here review their clinical and cytogenetic features.

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