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Biomarkers Volume 19, 2014 - Issue 1
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Research Article

Neutrophil gelatinase-associated lipocalin after off pump versus on pump coronary artery surgery

Miklos LipcseyDepartment of Surgical sciences, Section of Anaesthesiology & Intensive Care, Uppsala University UppsalaSweden
,
Philip HaywardDepartment of Cardiac Surgery, Austin Hospital MelbourneAustralia
,
Michael HaaseDepartment of Nephrology and Hypertension, Diabetes, and Endocrinology, Otto-von-Guericke-University MagdeburgGermany
,
Ania Haase-FielitzDepartment of Nephrology and Hypertension, Diabetes, and Endocrinology, Otto-von-Guericke-University MagdeburgGermany
,
Glenn EastwoodDepartment of Intensive Care, Austin Hospital MelbourneAustralia
,
Leah PeckDepartment of Intensive Care, Austin Hospital MelbourneAustralia
,
George MatalanisDepartment of Cardiac Surgery, Austin Hospital MelbourneAustralia
&
Rinaldo BellomoAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Centre, Prahran MelbourneAustraliaCorrespondence[email protected]
 show all
Pages 22-28 | Received 11 Sep 2013, Accepted 05 Nov 2013, Published online: 30 Jan 2014
 
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Abstract

Context: Cardiac surgery.

Objective: To compare plasma and urinary neutrophil gelatinase-associated lipocalin (P-/U-NGAL) in on-pump (n = 43) versus off-pump (n = 40) surgery.

Materials and methods: We obtained perioperative P-/U-NGAL and outcome data.

Results: P-/U-NGAL increased after surgery. P-NGAL was higher post-surgery in on pump patients (139 versus 67 µg L−1; p < 0.001), but not at 24 h. There were no differences in U-NGAL. Correlation between P-/U-NGAL and plasma creatinine was weak.

Discussion: P-NGAL acts like a neutrophil activation biomarker and U-NGAL like a tubular injury marker.

Conclusion: On-pump patients had greater neutrophil activation. On- versus off-pump surgery had similar impact on tubular cells.

Acknowledgements

We thank Leah Peck and Helen Young for their assistance with collection and measurement of NGAL levels.

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