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Hemoglobin
international journal for hemoglobin research
Volume 31, 2007 - Issue 3
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Short Communication

Genetic Origin of Hb D-Los Angeles [β121(GH4)Glu→Gln, GAA→CAA] According to the β-Globin Gene Cluster Haplotypes

Erol Ö. Atalay Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli, TurkeyCorrespondence[email protected]
,
Ayfer Atalay Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli, Turkey
,
Emre Üstel Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey
,
Sanem Yildiz Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey; Pamukkale University Research Center for Genetic Engineering and Biotechnology, Denizli, Turkey
,
Onur Öztürk Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey
,
Aylin Köseler Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey
&
Anzel Bahadir Department of Biophysics, Medical Faculty, Pamukkale University, Denizli, Turkey
 show all
Pages 387-391 | Received 14 Jul 2006, Accepted 22 Sep 2006, Published online: 07 Jul 2009
 
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Abstract

Hb D-Los Angeles (also known as D-Punjab, D-North Carolina, D-Portugal, D-Chicago and Oak Ridge) is an abnormal hemoglobin (Hb) with an amino acid substitution of glutamine for glutamic acid at codon 121 of the β-globin gene. The origin and spread of Hb D-Los Angeles is not known. This is due to lack of information and remains to be elucidated. According to published reports, the Hb D-Los Angeles mutation is mostly linked with Mediterranean haplotype I [+ − − − − + +]. Besides the Mediterranean haplotype, a novel haplotype was also reported from Thailand [− − + + − − + + +]. Here we report a new haplotype from Turkey [− + −− + + +] that has not been described before. These results suggest that the Hb D-Los Angeles mutation has at least three different genetic origins.

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