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Abstract
In this pilot study, we have investigated the effects of switching from olanzapine or risperidone treatment to low-dose perphenazine combined with buspirone in six schizophrenic patients who had experienced weight gain. We found no relapse as to psychotic symptoms measured by the CGI-S scale and no exacerbation of extrapyramidal side-effects as measured by the Simpson–Angus Scale. In addition, we observed a medium weight reduction of 10.5 kg (range 1–20 kg).
Andersen TH, Bech P, Larsen N-E. Switching patients from olanzapine or risperidone to a combination treatment using perphenazine plus buspirone: Evaluation of antipsychotic efficacy and side-effects, including extrapyramidal effects and weight loss. Nord J Psychiatry 2005;59:3. Oslo. ISSN 0803-9488.
Andersen TH, Bech P, Larsen N-E. Switching patients from olanzapine or risperidone to a combination treatment using perphenazine plus buspirone: Evaluation of antipsychotic efficacy and side-effects, including extrapyramidal effects and weight loss. Nord J Psychiatry 2005;59:3. Oslo. ISSN 0803-9488.