![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Hyperthermia (42–44°C for 30 min to 1 h) can induce apoptosis in a variety of cell types and tumour cell lines. This process is usually, but not invariably unaffected by RNA and protein synthesis inhibition. C-fos expression has been implicated in the regulation of apoptosis occurring under diverse circumstances. By heating the Burkitt lymphoma cell line, BM 13674, for 43°C for 30 min, approximately 60% of cells underwent apoptosis within 6 h of treatment. Co-ordinate with the massive induction of apoptosis, a 10-fold increase in the steady-state c-fos mRNA expression occurred.