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Leukemia & Lymphoma Volume 43, 2002 - Issue 10
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Research Article

Marked Thrombocytosis Following Relapse of Acute Myeloblastic Leukemia Associated with Development of Translocation (2;14) (p13;q32)

Taizo Tasaka First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan; Department of Medicine, Kagawa Prefectural Central Hospital, Kagawa, Japan
,
Masami Nagai First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan
,
Yoshiko Matsuhashi First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan; Department of Medicine, Kagawa Prefectural Central Hospital, Kagawa, Japan
,
Eisuke Uehara First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan
,
Naoki Kakazu Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Medicine, Kagawa Prefectural Central Hospital, Kagawa, Japan
,
Tatsuo Abe Department of Hygiene, Kyoto Prefectural University of Medicine, Kyoto, Japan
&
Takahiro Tamura First Department of Internal Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki-cho, Kagawa, 761-0793, Japan; Department of Medicine, Kagawa Prefectural Central Hospital, Kagawa, Japan
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Pages 2063-2065 | Published online: 03 Aug 2009
 
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Abstract

Thrombocytosis is a rare finding in acute myeloblastic leukemia (AML). Here, we describe a patient with AML who relapsed with marked thrombocytosis. The patient was initially diagnosed as having AML (M4) with a low platelet count. The patient was started on combination chemotherapy including high-dose etoposide and achieved complete remission. However, the patient relapsed six months later with an extremely high platelet count (72.5 2 10 4 / w l). Cytogenetic analysis at relapse revealed the development of t(2;14)(p13;q32). Despite the repeated combination chemotherapy, the patient died with progressive disease. This case suggests that the additional chromosomal aberration t(2;14)(p13;q32) may be related to abnormal thrombocytosis in AML.

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