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Cancer Investigation Volume 4, 1986 - Issue 5
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Original Article

Canine Oral Melanoma: Comparison of Surgery Versus Surgery Plus Corynebacterium parvum

E. Gregory MacEwen Department of Medical Sciences, School of Veterinary Medicine University of Wisconsin-Madison Madison, 53706, Wisconsin
,
A. K. Patnaik Donaldson-Atwood Cancer Clinic Animal Medical Center, 510 E 62 Street, New York, 10021, New York
,
H. J. Harvey Department of Surgery, New York State College of Veterinary Medicine Cornell University, Ithaca, 14853, New York
,
A. A. Hayes Donaldson-Atwood Cancer Clinic Animal Medical Center, 510 E 62 Street, New York, 10021, New York
&
R. Matus Donaldson-Atwood Cancer Clinic Animal Medical Center, 510 E 62 Street, New York, 10021, New York
Pages 397-402 | Published online: 11 Jun 2009
 
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Abstract

Eighty-nine dogs with malignant oral melanoma were selected for study. All dogs were clinically staged and treated with either surgical excision alone or surgery plus C. parvum immunotherapy. There was no difference in survival time between the two treatment groups. However, in dogs with advanced disease (Stages II, III) there-was a statistical difference between surgery alone versus surgery plus C. parvum (p = 0.01). Dogs with Stage I disease (tumor < 2 cm diameter) had a statistically improved survival (p = 0.02) regardless of the therapy given. These results suggest that C. parvum, when combined with surgery, may have antitumor activity in the canine melanoma model.

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