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Pediatric Hematology and Oncology Volume 9, 1992 - Issue 2
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Miscellaneous Article

Idiopathic Hypereosinophilic Syndrome Terminating in Acute Lymphoblastic Leukemia

Julie Blatt Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, Pennsylvania, 15213-3417, USA
,
Roy Proujansky Division of Gastroenterology, Department of Pediatrics, Children's Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, Pennsylvania, 15213-3417, USA
,
Marianna Horn Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, Pennsylvania, 15213-3417, USA
,
Carol Phebus Division of Hematology/Oncology, Department of Pediatrics, Children's Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, Pennsylvania, 15213-3417, USA
,
David Longworth Division of Infectious Diseases, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, 44195-5217, USA
&
Lila Penchansky Department of Pathology, University of Pittsburgh School of Medicine, DeSoto and O'Hara Streets, Pittsburgh, Pennsylvania, 15213, USA
Pages 151-155 | Received 08 Apr 1991, Accepted 16 Aug 1991, Published online: 09 Jul 2009
 
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Abstract

Idiopathic hypereosinophilic syndrome (IHES) is a heterogeneous group of disorders characterized by multisystem dysfunction and persistent, extreme eosinophilia of unknown cause. Hi describe a 9-1/2-year-old boy whose course included several unusual clinical features and terminated 2 years after diagnosis in acute lymphoblastic leukemia (ALL). Serial studies suggest that leukemia was not present earlier in his course. We speculate that this child may have had an evolving lymphoproliferative syndrome with a terminal blast crisis to which the eosinophilia was a nonmalignant leukemoid reaction.

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