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Leukemia & Lymphoma Volume 38, 2000 - Issue 5-6
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Original Article

Atypical Chronic Myeloid Leukaemia with Trisomy 21 Mosaicism as a Sole Chromosomal Abnormality

D. Benedek First Department of Internal Medicine, University Hospital Köln, 50924, Köln
,
M. Kiehl Clinic for Bone Marrow Transplantation Haematology/Oncology, 55743, Idar-Oberstein, Germany
,
A. Draube First Department of Internal Medicine, University Hospital Köln, 50924, Köln
,
J. Chemnitz First Department of Internal Medicine, University Hospital Köln, 50924, Köln
,
V. Diehl First Department of Internal Medicine, University Hospital Köln, 50924, Köln
&
D. Söhngen First Department of Internal Medicine, University Hospital Köln, 50924, Köln
Pages 639-644 | Received 26 Dec 1999, Published online: 01 Jul 2009
 
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Abstract

We present a 46-year-old patient with Ph-chromosome negative, bcr-negative chronic myeloid leukaemia (CML) in accelerated phase with a clonal trisomy 21 in the leukaemic blast cells. A rapid progress of disease with appearance of monocytosis is described, showing similar features to chronic myelomonocytic leukaemia (CMML). Heterogeneous characteristics and possible distinction of these two entities are discussed.

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