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Leukemia & Lymphoma Volume 56, 2015 - Issue 10
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Original Articles: Clinical

Dealing with bone marrow biopsies in the staging of classical Hodgkin lymphoma: an old issue revisited in the 18F-fluorodeoxyglucose-positron emission tomography era

Marianne de Castro GonçalvesPathology, Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, BrazilCorrespondence[email protected]
,
Henrique Moura de PaulaPathology, University of Goias Medical School, Goiania, Brazil
,
Camila da Cruz Gouveia LinardiHematology, Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, Brazil
,
Juliano J CerciDivision of PET/CT, Quanta – Diagnóstico Nuclear, Curitiba, Brazil
,
Vera Lucia AldredPathology, University of São Paulo, São Paulo, Brazil
,
Sheila Aparecida Coelho SiqueiraPathology, Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, Brazil
,
Valeria BuccheriHematology, Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, Brazil
&
Maria Claudia Nogueira ZerbiniPathology, Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, Brazil
 show all
Pages 2883-2888 | Received 29 Sep 2014, Accepted 02 Feb 2015, Published online: 24 Mar 2015
 
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Abstract

Bone marrow biopsy is recommended for staging of classical Hodgkin lymphoma. The aim of this study was to compare bone marrow evaluation by histology with that obtained by 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET). One hundred and three cases of Classical Hodgkin Lymphoma were reviewed. All patients were submitted to FDG-PET evaluation. Bone marrow biopsy results were compared with clinical data and FDG-PET results. Ninety-one cases had available bone marrow biopsies. Overall, there were 16 positive and one suspect case. In five cases, the FDG-PET scan was positive and biopsy was negative: 1/5 was found to correspond to a bone fracture, 3/5 showed marked reactive bone marrow changes and in 1/5 no explanation for the discrepancy was found. FDG-PET showed high sensitivity, supporting the idea that when it is negative, biopsy could be avoided. Care should be taken in patients with a positive FDG-PET, where confirmation by bone marrow biopsy should be recommended.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.

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