Advanced search
Publication Cover
Leukemia & Lymphoma Volume 7, 1992 - Issue 5-6
Submit an article Journal homepage
26
Views
2
CrossRef citations to date
0
Altmetric
Original Article

T-Cell Acute Lymphoblastic Leukemia with t(11;14) in Children

Raul C. Ribeiro Departments of Hematology-Oncology St. Jude Children's Research Hospital, and the Departments of Pediatrics and Pathology, University of Tennessee, Memphis, College of Medicine, Memphis, Tennessee, USA
,
Susana C. Raimondi Departments of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, and the Departments of Pediatrics and Pathology, University of Tennessee, Memphis, College of Medicine, Memphis, Tennessee, USA
,
Frederick G. Behm Departments of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, and the Departments of Pediatrics and Pathology, University of Tennessee, Memphis, College of Medicine, Memphis, Tennessee, USA
&
Ching-Hon Pui Departments of Hematology-Oncology St. Jude Children's Research Hospital, and the Departments of Pediatrics and Pathology, University of Tennessee, Memphis, College of Medicine, Memphis, Tennessee, USA; Departments of Pathology and Laboratory Medicine, St. Jude Children's Research Hospital, and the Departments of Pediatrics and Pathology, University of Tennessee, Memphis, College of Medicine, Memphis, Tennessee, USA
Pages 351-358 | Received 25 Feb 1992, Published online: 01 Jul 2009
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

We review and update our examination of the clinical and biologic findings in 19 cases of acute lymphoblastic leukemia (ALL) with the t(11;14) and discuss the literature relevant to the clinical, biologic, and molecular aspects of these translocations. In nine consecutively diagnosed cases at St. Jude Children's Research Hospital and 10 cases reported by other institutions, clinical features did not differ among T-cell ALL patients with and without the t(11;14), although leukemic cells with this translocation were more likely to coexpress CD4 and CD8 antigens. The t(11;14)(p13;q11) appears to occur exclusively in T-cell malignancies of intermediate- or late-stage thymocyte differentiation; further studies will be needed to determine whether it has prognostic significance.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,065.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.