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Leukemia & Lymphoma Volume 12, 1994 - Issue 3-4
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Original Article

Chronic Myelogenous Leukemia Following Repeated Radiation Therapy for Histiocytosis X

Linnea Chap Department of Medicine, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, California, USA
&
Stephen D. Nimer Department of Medicine, Division of Hematology/Oncology, UCLA School of Medicine, Los Angeles, California, USA
Pages 315-316 | Received 20 Apr 1993, Published online: 01 Jul 2009
 
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Abstract

Low dose radiotherapy has been used to treat a variety of benign disorders including Histiocytosis X. Ionizing radiation may be leukemogenic with leukemia developing between 3.5 to 11 years after exposure. Twenty to 30% of these leukemias are chronic myelogenous leukemia (CML). In this report the rare development of PH1 + CML 11 years after radiation therapy for Histiocytosis X is recorded.

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