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Leukemia & Lymphoma Volume 30, 1998 - Issue 3-4
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Original Article

Familial Erythroleukemia: A Distinct Clinical and Genetic Type of Familial Leukemias

Yelena Novik Department of Oncology, Montefiore Medical Center/Albert Einstein Cancer Center, 111 E 210th street, Bronx, NY, 10467, USA
,
Patricia Marino Department of Oncology, Montefiore Medical Center/Albert Einstein Cancer Center, 111 E 210th street, Bronx, NY, 10467, USA
,
Della F. Makower Department of Oncology, Montefiore Medical Center/Albert Einstein Cancer Center, 111 E 210th street, Bronx, NY, 10467, USA
&
Peter H. Wiernik Department of Oncology, Montefiore Medical Center/Albert Einstein Cancer Center, 111 E 210th street, Bronx, NY, 10467, USA
Pages 395-401 | Received 20 Aug 1997, Published online: 01 Jul 2009
 
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Abstract

A family with erythroleukemia is presented, in which father and son were diagnosed at the same age, but 20 years apart, with almost identical clinical and morphological features of the disease. No environmental factors were identified. The karyotypic abnormalities of the bone marrow blasts in the son demonstrated 2 major clones, involving chromosomes 5 and 7, as well as 8, 13, 16 and 21. Both patients demonstrated a poor response to chemotherapy. Previously described families with erythroleukemia are reviewed with available specific karyotypic aberrations.

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