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Ophthalmic Paediatrics and Genetics Volume 7, 1986 - Issue 3
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Original Article

Optic atrophy in Wolfram syndrome

A. T. Mtanda Institute of Ophthalmology, University of Nijmegen, The Netherlands
,
J. R. M. Cruysberg Institute of Ophthalmology, University of Nijmegen, The Netherlands
&
A. J. L. G Pinckers Institute of Ophthalmology, University of Nijmegen, The Netherlands
Pages 159-165 | Published online: 08 Jul 2009
 
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Abstract

The clinical and electrophysiologic findings in 11 cases of Wolfram syndrome are presented. These findings suggest that optic atrophy in Wolfram syndrome is not secondary to retinal pathology, but probably represents part of a generalized degeneration of neural structures. The relationship of diabetes mellitus to this process of neural degeneration remains unclear.

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