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Journal of Maternal-Fetal Medicine Volume 4, 1995 - Issue 3
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Original Article

Prenatal Identification of a Tetraploid Fetus with fish

Gregory L. Goyert Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sinai Hospital, and Wayne State University School of Medicine, Detroit, Michigan
,
Robin B. Gold Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sinai Hospital, and Wayne State University School of Medicine, Detroit, Michigan
,
Steven H. Mandell Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sinai Hospital, and Wayne State University School of Medicine, Detroit, Michigan
,
Richard A. Bronsteen Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sinai Hospital, and Wayne State University School of Medicine, Detroit, Michigan
,
Debra J. Wright Departments of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sinai Hospital, and Wayne State University School of Medicine, Detroit, Michigan
&
Brian E. Ward Integrated Genetics Laboratories Inc., Framingham, Massachusetts
Pages 96-99 | Received 02 Jan 1995, Accepted 06 Feb 1995, Published online: 07 Jul 2009
 
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Abstract

The first prenatal diagnosis of a tetraploid fetus via fluorescent in situ hybridization (FISH) technology is reported. FISH analysis of uncultured amniotic fluid cells utilizing probes for chromosomes 13, 21, 18, X, and Y revealed that greater than 65% of hybridized nuclei had four signals. Standard cytogenetic analysis revealed a 92, XXXX karyotype

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