Resident tissue macrophages within the normal rat iris lack immunosuppressive activity and are effective antigen-presenting cells

References

• Barker CF, Billingham RE.Immunologically privileged sites. Adv Immunol 1977;25:1–54.
   PubMed Web of Science ®Google Scholar
• Streilein JW, Ksander BR, TaylorAW. Immune deviation in relation to ocular immune privilege. J Immunol 1997;158:3557-356o.
   Google Scholar
• Streilein JW, Niederkorn JY.Induction of anterior chamber-associated immune deviation requires an intact, functional spleen. J Exp Med 1981;153:1o58-1o67.
   Google Scholar
• Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TS. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 1995;270:I 189–1192.
   Google Scholar
• Yamagami S, Kawashima H,Yamagami H, Kayagaki N, Yagita H, Okumura K, Gregerson DS. Role of Fas-Fas ligand interactions in the immmunorejection of allogeneic mouse corneal transplants. Transplantation 1997;64:1107–1111.
   Google Scholar
• Cousins SW, McCabe MM, Danielpour D, Streilein JW. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci 1991;32:220 I–
   Google Scholar
• Taylor AW, Streilein JW, CousinsSW. Identification of alpha- melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humour. Curr Eye Res 1992;u:1199–1206.
   Google Scholar
• Taylor AW, Streilein JW, Cousins SW. Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor. J Immunol 1994;153:1080–1086.
   Google Scholar
• Knisely TL, Hosoi J, Nazareno R, Granstein RD. The presence of biologically significant concentrations of glucocorticoids but little or no cortisol binding globulin within aqueous humour: relevance to immune privilege in the anterior chamber of the eye. Invest Ophthalmol Vis Sci 1994;35:3711–3723.
   PubMed Web of Science ®Google Scholar
• Streilein JW, Wilbanks GA, Cousins SW. Immunoregulatory mechanisms of the eye. J Neuroimmunol 1992;39:185–200.
   PubMed Web of Science ®Google Scholar
• Ganz T. Macrophage function. New Horiz 1993;1:23–27.
   PubMedGoogle Scholar
• Holt PG. Regulation of antigen-presenting cell function(s) in lung and airway tissues. Eur Respir J 1993;6:120–129.
   PubMed Web of Science ®Google Scholar
• Soesatyo M, Biewenga J, Van Rooijen N, Kors N, Sminia T. The in situ immune response of the rat after intraperitoneal depletion of macrophages by liposomeencapsulated dichloromethylenediphosphonate. Res Immunol 1991;142:533–540.
   Google Scholar
• Pavli P, Woodhams CE, Doe WF, Hume DA. Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria. Immunology 1990;70:40–47.
   PubMed Web of Science ®Google Scholar
• Thepen T, McMenamin C, Oliver J, Kraal G, Holt PG. Regulation of immune responses to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity. Eur J Immunol 1991;21:2845–2850.
   Google Scholar
• Strickland D, Kees UR, Holt PG. Regulation of T cell activation in the lung: alveolar macrophages induce reversible T-cell anergy in vitro associated with inhibition of interleukin-2 receptor signal transduction. Immunology 1996;87: 250–258.
   Google Scholar
• Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998;392:245–252.
   PubMed Web of Science ®Google Scholar
• McMenamin PG, Crewe J, Morrison S, Holt PG. Immunomorphologic studies of macrophages and MHC class II-positive dendritic cells in the iris and ciliary body of the rat, mouse, and human eye. Invest Ophthalmol Vis Sci 1994;35:3234–3250.
   PubMed Web of Science ®Google Scholar
• Steptoe RJ, Holt PG, McMenamin PG. Functional studies of major histocompatibility class II-positive dendritic cells and resident tissue macrophages isolated from rat iris. Immunology 1995;85:630–637.
   Google Scholar
• Wilbanks GA, Mammolenti M, Streilein JW. Studies on the induction of anterior chamber-associated im-mune deviation (ACAID) III. Induc-tion of ACAID depends on intraocular transforming growth factor-13. Eur J Immunol 1992;22: 165–173.
   Google Scholar
• Hara Y, Okamoto S, Rouse B, Streilein JW. Evidence that peritoneal exudate cells cultured with eye-de-rived fluids are the proximate antigen-presenting cells in immune deviation of the ocular type. J Immunol 1993;151:5162–5171.
   PubMed Web of Science ®Google Scholar
• Holt PG, Schon-Hegrad MA, Oliver J. MHC class II antigen-bearing den-dritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations. J Exp Med 1988;167:262–274.
   Google Scholar
• Harding CV, Roof RW, Unanue ER. Turnover of la-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchange. Proc Natl Acad Sci USA 1989;86:4230–4234.
   Google Scholar
• Kampgen E, Koch N, Stoger P, Heufler C, Schuler G, Romani N. Class II major histocompatibility com-plex molecules of murine dendritic cells: synthesis, sialylation of invari-ant chain, and antigen processing ca-pacity are down regulated upon cul-ture. Proc Natl Acad Sci USA 1991;88:3o14-3o18.
   Google Scholar
• Holt PG. Down-regulation of immune responses in the lower respiratory tract: the role of alveolar macrophages. Clin Exp Immunol 1986;63:261–270.
   PubMed Web of Science ®Google Scholar
• Holt PG, Oliver J, Bilyk N, McMenamin C, McMenamin PG, Kraal G, Thepen T. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 1993;177:397–407.
   Google Scholar
• Roland CR, Walp L, Stack RM, Flye MW. Outcome of Kupffer cell antigen presentation to a cloned murine Thi lymphocyte depends on the inducibility of nitric oxide synthase by IFN-y. J Immunol 1994;153:5453–5464.
   PubMed Web of Science ®Google Scholar
• Taylor AW, Yee DG, Streilein JW. Suppression of nitric oxide generated by inflammatory macrophages by calcitonin gene-related peptide in aqueous humor. Invest Ophthalmol Vis Sci 1999;39:1372–1378.
   Google Scholar
• Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DJ, Srimal S. Mac-rophage deactivating factor and trans-forming growth factors-13i, 432 and - P3 inhibit induction of nitrogen oxide synthase by interferon-y. J Immunol 199o;145:94o–944.
   Google Scholar
• McMenamin PG, Crewe J. Endotoxin induced uveitis: kinetics and pheno-type of the inflammatory cell infiltrate and the response of the resident tissue macrophage and dendritic cells in the iris and ciliary body. Exp Eye Res 1995;65:157–164.
   Web of Science ®Google Scholar
• Butler TL, McMenamin PG. Resident and infiltrating immune cells in the uveal tract in the early and late stages of experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci 1996; 37:2195–2210.
   PubMed Web of Science ®Google Scholar
• Prendergast RA, Iliff CE, Coskuncan NM, Caspi RR, Sartani G, Tarrant TK, Lutty GA, McLeod DS. T cell traffic and the inflammatory response in experimental autoimmune uveoreti-nitis. Invest Ophthalmol Vis Sci 1998;39:754–762.
   PubMed Web of Science ®Google Scholar
• O'Connor GR. Endogenous uveitis. In: Kraus-Mackiw E, O'Connor GR, editors. Uveitis: Pathology and Therapy. New York: Thieme-Stratton Inc, 1983; 45–116.
   Google Scholar
• Wilbanks GA, Streilein JVV. Studies on the induction of anterior chamber-associated immune deviation (ACAID). 1. Evidence that an antigen-specific, ACAID-inducing, cell-asso-ciated signal exists in the peripheral blood. J Immunol 1991;146: 2610–2617.
   Google Scholar
• Austyn JM, Hankins DF, Larsen CP, Morris PJ, Rao AS, Roake JA. Isola-tion and characterization of dendritic cells from mouse heart and kidney. J Immunol 1994;152:2401–2410.
   PubMed Web of Science ®Google Scholar
• Steptoe RJ, Holt PG, McMenamin PG. Origin and steady-state turnover of major histocompatibility complex class II-positive dendritic cells and resident-tissue macrophages in the iris of the rat eye. J Neuroimmunol 1996;68:67–76.
   Google Scholar
• McMenamin PG, Forrester JV. Den-dritic cells in the central nervous sys-tem and eye and their associated sup-porting structures. In: Lotze ML, Thomson AW, editors. Dendritic Cells: Biology and Clinical Applica-tions. London: Academic Press, 1998; 205–248.
   Google Scholar
• Egan RM, Yorkey C, Black R, Loh WK, Stevens JL, Woodward JG. Pep-tide-specific T cell clonal expansion in vivo following immunization in the eye, an immune-privileged site. J Immunol 1996;157:2262–2271.
   PubMed Web of Science ®Google Scholar
• Steptoe RJ, Thomson AW. Dendritic cells in tolerance induction. Clin Exp Immunol 1996;105:397–402.
   PubMed Web of Science ®Google Scholar