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Ocular Immunology and Inflammation Volume 11, 2003 - Issue 1
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Research Article

Splenic T cells from mice receiving intracameral antigen suppress in-vitro antigen-induced proliferation and interferon-? production by sensitized lymph node cells

Yafei Wang Department of Pathology, Vision Immunology Center, University of Connecticut Health Center, Farmington, CT, USA
,
Wa-el Ghali Department of Pathology, Vision Immunology Center, University of Connecticut Health Center, Farmington, CT, USA
,
Pavani Pingle Department of Pathology, Vision Immunology Center, University of Connecticut Health Center, Farmington, CT, USA
,
Amar Traboulsi Department of Pathology, Vision Immunology Center, University of Connecticut Health Center, Farmington, CT, USA
,
Tajas Dalal Department of Pathology, Vision Immunology Center, University of Connecticut Health Center, Farmington, CT, USA
,
James O’Rourke Department of Pathology, Vision Immunology Center, University of Connecticut Health Center, Farmington, CT, USA
&
Robert E. Cone Department of Pathology, Vision Immunology Center, University of Connecticut Health Center, Farmington, CT, USA
 show all
Pages 39-52 | Published online: 08 Jul 2009

References

  • Streilein JW. Immune regulation and the eye: a dangerous compromise. FASEB J. 1987;1:199–208.
  • Ferguson TA, Waldrep JC, Kaplan HJ. The immune response and the eye: the nature of T suppressor cell induction in anterior chamber associated immune deviation. (ACAID). J Immunol. 1987;139:352–357.
  • Wilbanks GA, Streilein JVV. Distinctive humoral immune responses following anterior chamber and intravenous administration of soluble antigen. Evidence for active suppression of IgG2-secreting B lymphocytes. Immunology. 1990;71:566–572.
  • Wilbanks GA, Streilein JW. Macrophages capable of inducing anterior chamber associated immune deviation demonstrate spleen-seeking migratory properties. Reg ImmunoL 1992;4:13o–137.
  • Wang Y, Goldschneider I, Foss D, Wu DY, O'Rourke J, Cone RE. Direct thymic involvement in anterior chamber-associated immune deviation. Evidence for a nondeletional mechanism of centrally-induced tolerance to extrathymic antigen in adult mice. J ImmunoL 1997;158:2150–2155.
  • Wang Y, Goldschneider I, O'Rourke J, Cone RE. Establishment of systemic tolerance through an immune privileged site requires the induction of regulatory NKT thymocytes by peripheral blood mononuclear cells. J Leukocyte Biol. 2001;69:741–746.
  • Wilbanks GA, Streilein JVV. Characterization of suppressor cells in anterior chamber-associated immune deviation induced by soluble antigen. Evidence of two functionally and phenoytpically distinct T-suppressor cell populations. Immunology. 1990;71: 383–389.
  • D'Orazio TG, Niederkorn JY. Splenic B cells are required for tolerogenic antigen presentation in the production of anterior chamber-associated immune deviation. Immunology. 1998;95:47–55.
  • Faunce DE, Sonoda K-H, Stein-Streilein J. MIP-2 mediated recruitment of NKT cells to the spleen during tolerance induction. J ImmunoL 2001166:313–321.
  • Wilbanks GA, Mammolenti M, Streilein JW. Studies in the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID. J ImmmunoL 1991;146:3018–3024.
  • D'Orazio TG, Neiderkorn JY. A novel role for TGF-I3 and IL-10 in the induction of immune privilege. J ImmunoL 1998;160:2089–2098.
  • Wilbanks GA, Mammolenti M, Streilein JVV. Studies on the induction of anterior chamber-associated immune deviation (ACAID). III. Induction of ACAID depends upon intraocular transforming growth factor-beta. Eur J ImmunoL 1992;22:165–173.
  • Hara M, Kingsley CJ, Niimi M, Read S, Turvey SE, Bushell AR, Morris PJ, Powrie FA. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J ImmunoL 2001;166:3789–3796.
  • Annacker ORP-A, Burlen-Defranoux 0, Barbosa TC, Cumano A, AB. CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-1o. J ImmunoL 2001;166: 3008–3018.
  • Sonoda K-H, Exly M, Snapper S, Bulk ST, Stein-Streilein J. CD-I-reactive natural killer T cells are required for the development of systemic tolerance through a privileged site. J Exp Med. 1999;180: 1215–1226.
  • Skelsey ME, Mellon J, Niederkorn JY. Gamma delta T cells are needed for ocular immune privilege and corneal graft survival. J Immunol. 2001;166:4327–4333.
  • Skelsey ME, Neiderkorn J. ACAID CD4+ T cells must provide IL-10 for the generation of ACAID efferent suppressor cells (Abstract). Invest Ophthalmol Vis ScL 2001;42:8474.
  • Kosiewicz MM, Alard P, Streilein JVV. Alterations in cytokine production following intraocular injection of soluble protein antigen: impairment in IFN-gamma and induction of TGF-beta and IL-4 production. J ImmunoL 1998;161: 5382-539o.
  • Li XY, D'Orazio LT, Niederkorn JY. Role of Thi and Thz cells in anterior chamber-associated immune deviation. Immunology. 1996;89:34–40.
  • Cochrane R, Clark RB, Huang CK, Cone RE. Differential regulation of T cell receptor-mediated Thi cell IFN-gamma production and proliferation by divergent cAMP-mediated redox pathways. J Interferon Cytokine Res. 2001;21:707–807.

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