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Ocular Immunology and Inflammation Volume 6, 1998 - Issue 1
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Research Article

Topical liposome-encapsulated FK506 for the treatment of endotoxin-induced uveitis

Scott M. Whitcup National Eye Institute, National Institutes of Health, Bethesda, MD, USA
,
Uwe Pleyer Department of Ophthalmology, Charite, Humboldt University, Berlin, Germany
,
James C. Lai National Eye Institute, National Institutes of Health, Bethesda, MD, USA
,
Sabine Lutz Department of Ophthalmology, Charite, Humboldt University, Berlin, Germany
,
Manabu Mochizuki Department of Ophthalmology, School of Medicine, Kurume University, Kurume, Japan
&
Chi-Chao Chan National Eye Institute, National Institutes of Health, Bethesda, MD, USA
Pages 51-56 | Published online: 08 Jul 2009

References

  • Goto T, Kino T, Hatanaka H, et al. FK506: historical perspectives. Transplant Proc 1991;23:2713–2717.
  • Ni M, Chan C-C, Nussenblatt RB, Mochizuki M. FR900506 (FK506) and 15-deoxyspergualin (15-DSG) modulate the kinetics of infiltrating cells in eyes with experimental au-toimmune uveoretinitis. Autoim-munity 1990;8: 43–51.
  • Fujino Y, Mochizuki M, Chan C-C, et al. FK506 treatment of Santigen induced uveitis in primates. Curr Eye Res 1991;1o:679–690.
  • Kino T, Hatanaka H, Miyata S, et al. FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506. J Antibiot (Tokyo) 1987;40: 1256–1265.
  • Sawada S, Suzuki G, Kawase Y, Takaku F. Novel immunosuppressive agent FK506: in vitro effects on the cloned T cell activation. J Immunol 1987139:1797-1803.
  • Kino T, Inamura N, Sakai F, et al. Effect of FK506 on human mixed lymphocyte reaction in vitro. Transplant Proc 1987;19:36–39.
  • Mochizuki M, Masuda K, Sakane T, et al. A multicenter clinical open tri-al of FK 506 in refractory uveitis including Behçet's disease. Transplant Proc 1991;23:3343–3346.
  • Hikita N, Chan CC, Whitcup SM, Nussenblatt RB, Mochizuki M. Effects of topical FK506 on endotoxin-induced uveitis (EIU) in the Lewis rat. Curr Eye Res 1995;14: 209–214.
  • Pleyer U, Lutz S, Jusko WJ, et al. Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye. Invest Ophthalmol Vis Sci 1993;34:2737–2742.
  • Kogiso M, Tanouchi Y, Mimura Y, Nagasawa H, Himeno K. Endotoxin-induced uveitis in mice 1. Induction of uveitis and role of T lymphocytes. Jpn J Ophthalmol 1992;36: 281–290.
  • Holland EJ, Olsen TW, Ketcham JM, et al. Topical cyclosporin A in the treatment of anterior segment inflammatory disease. Cornea 1993;12:413–419.

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