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Research Article

L-Canavanine: A Potential Chemotherapeutic Agent for Human Pancreatic Cancer

Pages 194-201 | Published online: 29 Sep 2008

REFERENCES

  • Allende CC, Allende JE (1964): Purification and substrate specificity of arginyl-ribonucleic acid synthetase from rat liver. J Biol Chem 239: 1102–1106.
  • Berge MA, Rosenthal GA, Dahlman DL (1986): Tobacco budworm, Heliothis virescens (Noctuidae) resistance to L-canavanine, a protective allelochemical. Pest Biochem Physiol 25: 319–326.
  • Bleiler J, Rosenthal GA, Janzen DH (1988): Biochemical ecology of canavanine-eating seed predators. Ecol 69: 427–433.
  • Boyar A, Marsh RE (1982): L-Canavanine, a paradigm for the structures of substituted guanidines. J Am Chem Soc 104: 1995–1998.
  • Dahlman DL, Rosenthal GA (1976): Further studies on the effect of L-canavanine on the tobacco hornworm, Mand-uca sexta (L.) (Sphingidae). J Insect Physiol 22: 265–271.
  • Green MH, Brooks TL, Mendelsohn J, Howell SB, (1980): Antitumor activity of L-canavanine against L1210 murine leukemia. Cancer Res 40: 535–537.
  • Green MH, Ward JF (1983): Enhancement of human tumor cell killing by L-canavanine in combination with 'y-radia-tion. Cancer Res 43: 4180'1182.
  • Greenstein JP, Winitz M (1963): Chemistry of the Amino Acids, Vols. 1-3. New York, Wiley & Sons.
  • Keppi E, Zachary D, Robertson M, Hoffmann D, Hoffmann J(1986): Induced antibacterial proteins in the hemolymph of Phormia terranovae (Diptera). Purification and possi-ble origin of one protein. Insect Biochem 16: 395–399.
  • Kruse Jr, PF, McCoy TA (1958): The competitive effect of canavanine on utilization of arginine in growth of Walker carcinosarcoma 256 cells in vitro. Cancer Res 18: 279–282.
  • Kruse Jr, PF, White PB, Carter HA, McCoy TA (1959): Incor-poration of canavanine into protein of Walker carcinosar-coma 256 cells cultured in vitro. Cancer Res 19: 122–125.
  • Melangeli C, Rosenthal GA, Dahlman DL (1997): The bio-chemical basis for the tolerance of Heliothis virescens to L-canavanine. Proc NatI Acad Sci USA 94: 255–2260.
  • Mitra SK, Mahler AH (1967): The arginyl transfer ribonu-cleic acid synthetase of Escherichia coli. J Biol Chem 242: 5490–5494.
  • Naha PM, Silcock JM, Fellows L (1980): An experimental model for selective inhibition of proliferating cells by chemotherapeutic agents. Cell Biol Inter Rept 4: 155–166.
  • NaPhuket S (1997): L-Canavanine and its Derivatives as Potential Chemotherapeutic Agents for Pancreatic Can-cer: Synthesis, Structure-Activity Relationships and Meta-bolic Studies. Ph.D. Thesis, University of Kentucky, 1997.
  • NaPhuket S,Trifonov LS, Crooks PA, Rosenthal GA, Free-man JW, Strodel WE (1997): Synthesis and structure-activity relationships of some antitumor congeners of L-canavanine. Drug Devel Res 40: 325–332.
  • Prouty WF, Karnovsky MJ, Goldberg AL (1972): Degrada-tion of abnormal proteins in Escherichia co/i. J Biol Chem 250: 1112–1122.
  • Rahiala EL, Kekomaki MK, Janne J, Raina A, Raiha NCR (1971): Inhibition of pyridoxal enzymes by L-canaline Biochim Biophys Acta 227: 337–343.
  • Rosenthal GA (1977): The biological effects and mode of action of L-canavanine, a structural analogue of L-argi-nine. Q Rev Biol 52: 155–178.
  • Rosenthal GA (1983): The adaptation of a beetle to a poiso-nous plant. Sci Am 249: 164–171.
  • Rosenthal GA, (1997): L-canaline: a potent antimetabolite and anti-cancer agent of leguminous plants. Life Sci 60: 1635–1641.
  • Rosenthal GA, Nkomo P, Dahlman DL (1998): The effect of long-chained esters on the insecticidal properties of L-canavanine. J Food Agric Sci 46: 296–299.
  • Rosenthal GA, Dahlman DL (1990): Interaction of L-canaline with ornithine aminotransferase of the tobacco hornworm, Manduca sexta (Sphingidae). J Biol Chem 265: 868–873.
  • Rosenthal GA, Nkomo P (1997): Unpublished data.
  • Rosenthal GA, Lambert J, Hoffmann D (1989a): L-Canava-nine incorporation into protein can impair macromolecu-lar function. J Biol Chem 264: 9768–9771.
  • Rosenthal GA, Reichhart JM, Hoffmann JA (1989b): L-Canavanine incorporation into vitellogenin and macro-molecular conformation. J Biol Chem 264: 13693–13696.
  • Rosenthal GA, Berge MA, Bleiler JA, Rudd T(1987): Avoid-ance of aberrant protein production and an organism's ability to utilize or tolerate L-canavanine. Experientia 43: 558–561.
  • Schachtele CF, Rogers P (1965): Canavanine death in Escherichia co/i. J Mol Biol 34: 843–860.
  • Swaffar DS, Ang CY, Desai PB, Rosenthal GA (1994): Inhi-bition of the growth of human pancreatic cancer cells by the arginine antimetabolite, L-canavanine. Cancer Res 54: 6045–6048.
  • Swaffar DS, Choo YA, Desai PB, Rosenthal GA, Thomas DA, John WJ, Crooks PA, (1995): Combination therapy with 5-fluorouracil and L-canavanine: in vitro and in vivo studies. Anti-Cancer Res 6: 586–593
  • Thomas DA, Rosenthal GA, Gold DV, Dickey K (1986): Growth inhibition of a rat colon tumor by L-canavanine. Cancer Res 46: 2898–2903
  • Thomas DA, Rosenthal GA (1987a): Toxicity and pharmaco-kinetics of the nonprotein amino acid L-canavanine in the rat. Toxicol Appl Pharm 91: 395–405.
  • Thomas DA, Rosenthal GA (1987b): Metabolism of L-[guanidinooxy-14C1-canavanine in the rat. Toxicol Appl Pharm 91: 406–414.

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