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Pharmaceutical Biology Volume 37, 1999 - Issue 1
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Research Article

Cytotoxic Activity of Some Indole Derivatives and Indole Metabolites of Streptomyces staurosporeus

Shu-Wei Yang Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
,
Geoffrey A. Cordell Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
,
Hee-Byung Chai Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
,
Mei-Shiang Jang Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
&
John M. Pezzuto Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Pages 67-70 | Published online: 29 Sep 2008

References

  • DeMarini DM, Cros S, Paoletti C, Lecointe P, Hsie AW (1983): Mutagenicity and cytotoxicity of five antitumor ellipticines in mammalian cells and their structure-activity relationships in Salmonella. Cancer Res 43: 35/M 3552.
  • Likhitwitayawuid K, Angerhofer CK, Cordell GA, Pezzuto JM, Ruangrungsi N (1993): Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Stephania erecta. J Nat Prod 56: 30–38.
  • Omura S, Iwai Y, Hirano A, Nakagawa A, Awaya J, Tsuchiya H, Takahashi Y, Masuma R (1977): A new alkaloid AM-2282 of Streptomyces origin, taxonomy, fermentation, iso-lation and preliminary characterization. J Antibiot 30: 275–282.
  • Shellard SA, Whelan RDH, Hill BT (1989): Growth inhibitory and cytotoxic effects of melatonin and its metabolites on human tumour cell lines in vitro. Br J Can-cer 60: 288–290, related references are cited here.
  • Yang S-W, Cordell, GA (1996): Biosynthesis of stauro-sporine: incorporation of glucose. J Nat Prod 59: 828–833.
  • Yang S-W, Cordell, GA (1997a): Deuterium labeling and mass fragmentation studies of staurosporine. J Nat Prod 60: 236–241.
  • Yang S-W, Cordell, GA (1997b): Metabolism studies of indole derivatives using a staurosporine producer, Strepto-myces staurosporeus. J Nat Prod 60: 4/1 /18.
  • Yang S-W, Cordell, GA (1997c): Further metabolic studies of indole and sugar derivatives using the staurosporine pro-ducer Streptomyces staurosporeus. J Nat Prod 60: 230–235.

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